Steering Committee

Our steering committee consists of our spokesperson, our vice-spokesperson, 2 PIs, our coordinator, a student´s ombudsperson (PI or postdoc, elected by our students) and 2 student representatives (1 PhD and 1 MD student). The members of the steering committee are committed to report to the DFG, mediate in case of conflicts, coordinate public outreach, manage all administrative hurdles and organize the educational program.

Members

Prof. Dr. Daniela Dieterich

Speaker RTG2413 & Director of the Institute for Pharmacology and Toxicology, Medical Faculty, OVGU,PI of Neural Plasticity and Communication

The work in my lab concentrates on the molecular and cellular underpinnings of protein homeostasis at the multipartite synapse and their consequences for brain function during aging. My major goals within the graduate program SynAGE is to guide young scientists along their ways to develop their very own line of research, to support the intersection of ideas across disciplines, and thereby to catalyze discovery.

Prof. Dr. Oliver Stork

Head of the Department of Genetics and Molecular Neurobiology, Institute of Biology, OVGU

My work is devoted to the understanding of molecular mechanisms that mediate information processing in the brain and the control of behavior. In my group we are particularly interested in long-term change in GABAergic interneurons that control local circuit activity as well as extended network activity patterns in the limbic brain system. Our focus lies on unraveling the intracellular pathways controlling homeostatic plasticity in both GABAergic and their excitatory target neurons. We address the role of these cells with molecular and physiological tools in cell culture, genetically manipulated mice and following acut viral interventions. 

Prof. Dr. Constanze Seidenbecher

Committee member, LIN

I am a group leader at the Leibniz Institute for Neurobiology (LIN) Magdeburg. My scientific interests are devoted to synaptic molecules and the brain extracellular matrix and their role in neuroplasticity and cognitive functions.

I am member of the Board of directors of the Center for Behavioral Brain Sciences (CBBS) Magdeburg, steering committee member of the SFB „Neurobiology of motivated behavior“ and deputy speaker of the graduate school ABINEP. In 2019 I was elected as council member of the International Society for Neurochemistry (ISN).

My aim is to further support excellent young scientists – with a special focus on female researchers – by connecting, inspiring and promoting young careers in SynAGE and beyond.

Dr. Michael R. Kreutz

Committee member, LIN

My research in NPlast in Magdeburg and DOF in Hamburg is concerned with fundamental questions on how synapses communicate with the nucleus, how gene activity-dependent gene expression feeds back to synaptic function and how this is related to the formation of a cellular engram and last but not least how the nanoscale organization of the synapse determines functional properties in the context of learning and memory. We use a multi-disciplinary approach with studies ranging from single molecules to in vivo animal experimentation. We also address translational aspects where we try to understand whether the processes that we investigate might be relevant for disease. The Leibniz Group ‚Dendritic Organelles and Synaptic Function‘ at the ZMNH in Hamburg investigates how microsecretory systems and organelles in neurites are involved in synaptic function. We are interested in organelles like autophagosomes, lysosomes, and Golgi satellites and their local contribution to neurotransmission.

Dr. Anika Dirks

Coordination of RTG 2413 SynAGE

After studying Biochemistry at the Martin Luther University Halle, I did my PhD in Molecularbiology and Neurochemistry at the Leibniz Institute for Neurobiologie Magdeburg. During that time, my life focused on the presynapse-to-nucleus shuttling protein CtBP1.

Since 2017, I have worked as scientific coordinator at LIN and OVGU, especially at the center for behavioral brain sciences cbbs and the cbbs graduate program. I like to help young motivated students to complete their MD or PhD, which I am looking forward to continue and intensify at SynAGE.

Projects

TP1:
Dysbalanced protein homeostasis as a hallmark and intervention target for aging cells? (Natalia Waal, Peter Landgraf and Daniela C. Dieterich)

TP2:
Autophagy mechanisms in the aging hippocampus (Carlos Miguel del Angel Munoz, Anne Albrecht and Oliver Stork)

TP3:
A nexus between DNA-hypomethylation and cognitive decline in healthy aging (Vsevolod Cherepashkin, Guilherme Gomes and Michael R. Kreutz)

TP4:
Molecular underpinnings of high-risk aging: Neuronal insulin signaling, amyloidosis and the metabolic syndrome (Eleonora Cuboni, Anna Karpova, Camilla Fusi, Alessandro Confettura and Michael R. Kreutz)

TP5:
The effect of immunosenescence on synapse composition in a chronic neuroinflammation model (Parichehr Kargaran, Johannes Steffen and Ildiko R. Dunay)

TP6:
Extracellular matrix-neuron-glia interactions during aging-associated cognitive decline and rejuvenation by ECM targeting (Hadi Mirzapourdelavar, Inseon Song, Rahul Kaushik and Alexander Dityatev)

TP7:
Targeting perisynaptic ECM mediated synaptic dysfunction in cerebral small vessel disease (Mahsima Khoshneviszadeh, Solveig Jandke, Rahul Kaushik, Stefanie Schreiber and Alexander Dityatev)

TP8:
The perisynaptic extracellular matrix (ECM) of the aging brain: impact of enriched environment and neuromodulation on ECM composition and cognitive performance (Jana Schulze, Eckart D. Gundelfinger and Constanze I. Seidenbecher)

TP9:
Mechanosensitive and astrocytic contributions to synaptic plasticity during aging (Danai Katsere, Anne Bayrhammer, Anke Müller and Daniela C. Dieterich)

TP10:
Hippocampal interneuron circuits during cognitive decline (Katharina Klinger, Gürsel Caliskan and Oliver Stork)

TP11:
Impact of stress on aging of BDNF-dependent synaptic and cognitive functions (Jeimmy Marcela Ceron Gonzalez, Thomas Endres and Volkmar Leßmann)

TP12:
Effects of L-DOPA on memory consolidation in high- and low-performing amyloid-negative older adults (Elisa Lancini, Dorothea Hammerer, Matthew Betts and Emrah Düzel)

TP13:
Learning from mistakes: Cholinergic modulation of interactions between performance monitoring and long-term memory (Alexander Weuthen and Markus Ullsperger)

News and Events

SynAGE Events

Past Events

08.10.2019 – 2nd Plenary Assembly

22.-23.05.2019 – RTG 2413 SynAGE Kick-Off Meeting

19.02.2019 – 1st Plenary Assembly

25.-26.10.2018 – Recruitment Symposium

SynAGE Lectures

SynAGE lecture series WS 2019/2020

Past Lectures

SynAGE lecture series SS 2019

SynAGE @

Company Relay – 27th June 2019

Among 5000 runners, also SynAGE members participated in the company relay 2019. Our team SynAGE: Running for healthy aging! Pari – team captain Eleonora Natalia Jana Vsevolod Alex Elisa More …

Career Day – 20th June 2019

Career Day – Perspectives for Women in Life Sciences Also this year, students took the chance to get information about several career opportunities and sharpening their soft skills and networks.SynAGE, …