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Our Research Training Group 2413 is an innovate research program funded by the DFG. We – 13 PhD students and their PIs – are dealing with the idea that cognitive decline in normal aging results from synaptic dysbalances. Hence, we are highly motivated to shed more light on altered synaptic proteostasis, dysfunctions of the immune system, altered functionality of the multipart synapse and changes in neuromodulation. | Unsere Graduiertenschule RTG 2413 ist ein von der DFG gefördertes innovatives Forschungsprogramm. Wir – das sind 13 Promotionsstudenten und ihre Betreuer – verfolgen die Idee, dass kognitiver Leistungsabfall während des normalen Alterns auf einem synaptischen Ungleichgewicht beruht. Deshalb wollen wir im Alter auftretende Prozesse wie veränderte synaptische Proteostase, Fehlfunktionen des Immunsystems, veränderte Funktionalität der Synapse und Veränderungen der Neuromodulation besser verstehen. | Notre école doctorale 2413 est un programme de recherche innovant financé par le DFG. Nous – 13 doctorants et leurs superviseurs – poursuivons des recherches sur l’idée que le déclin cognitif pendant un vieillissement normal est le résultat de déséquilibres synaptiques. C’est pourquoi nous voulons apporter de nouvelles informations sur l’altération de l’homéostasie protéique au niveau synaptique, les dysfonctionnements du système immunitaire, l’altération des fonctions de la synapse et les changements de la neuromodulation. | Nuestro Grupo de formacion en investigación 2413 es un innovador programa de investigación financiado por la DFG. Nosotros – 13 estudiantes de doctorado y sus IP – tratamos con la idea de que el deterioro cognitivo en el envejecimiento normal se debe a desequilibrios sinápticos. Por lo tanto, estamos muy motivados en arrojar más luz sobre proteostasis sináptica alterada, disfunciones del sistema inmunológico, la funcionalidad alterada de la sinapsis multiparte y cambios en la neuromodulación. | Il nostro Research Training Group 2413 è un innovativo programma di ricerca finanziato dalla DFG. Noi – 13 studenti di dottorato e il loro IP – trattiamo l’idea che il declino cognitivo nel normale invecchiamento sia dovuto a squilibri sinaptici. Pertanto, siamo molto motivati a gettare più luce sulla protestasi sinaptica alterata, disfunzioni del sistema immunitario, alterata funzionalità della sinapsi multiparti e cambiamenti nella neuromodulazione.
committee consists of our spokesperson, our vice-spokesperson, 2 PIs, our
coordinator, a student´s ombudsperson (PI or postdoc, elected by our students)
and 2 student representatives (1 PhD and 1 MD student). The members of the
steering committee are committed to report to the DFG, mediate in case of
conflicts, coordinate public outreach, manage all administrative hurdles and
organize the educational program.
Prof. Dr. Daniela Dieterich
Spokesperson RTG2413, Dean of the Medical Faculty, Director of the Institute for Pharmacology and Toxicology, &PI of Neural Plasticity and Communication
The work in my lab concentrates on the molecular and cellular underpinnings of protein homeostasis at the multipartite synapse and their consequences for brain function during aging. My major goals within the graduate program SynAGE is to guide young scientists along their ways to develop their very own line of research, to support the intersection of ideas across disciplines, and thereby to catalyze discovery.
Prof. Dr. Oliver Stork
Head of the Department of Genetics and Molecular Neurobiology, Institute of Biology, OVGU
My work is devoted to the understanding of molecular mechanisms that mediate information processing in the brain and the control of behavior. In my group we are particularly interested in long-term change in GABAergic interneurons that control local circuit activity as well as extended network activity patterns in the limbic brain system. Our focus lies on unraveling the intracellular pathways controlling homeostatic plasticity in both GABAergic and their excitatory target neurons. We address the role of these cells with molecular and physiological tools in cell culture, genetically manipulated mice and following acut viral interventions.
Prof. Dr. Constanze Seidenbecher
Committee member, LIN
I am a group leader at the Leibniz Institute for Neurobiology (LIN) Magdeburg. My scientific interests are devoted to synaptic molecules and the brain extracellular matrix and their role in neuroplasticity and cognitive functions.
I am member of the Board of directors of the Center for Behavioral Brain Sciences (CBBS) Magdeburg, steering committee member of the SFB „Neurobiology of motivated behavior“ and deputy speaker of the graduate school ABINEP. In 2019 I was elected as council member of the International Society for Neurochemistry (ISN).
My aim is to further support excellent young scientists – with a special focus on female researchers – by connecting, inspiring and promoting young careers in SynAGE and beyond.
Dr. Michael R. Kreutz
Committee member, LIN
My research in NPlast in Magdeburg and DOF in Hamburg is concerned with fundamental questions on how synapses communicate with the nucleus, how gene activity-dependent gene expression feeds back to synaptic function and how this is related to the formation of a cellular engram and last but not least how the nanoscale organization of the synapse determines functional properties in the context of learning and memory. We use a multi-disciplinary approach with studies ranging from single molecules to in vivo animal experimentation. We also address translational aspects where we try to understand whether the processes that we investigate might be relevant for disease. The Leibniz Group ‚Dendritic Organelles and Synaptic Function‘ at the ZMNH in Hamburg investigates how microsecretory systems and organelles in neurites are involved in synaptic function. We are interested in organelles like autophagosomes, lysosomes, and Golgi satellites and their local contribution to neurotransmission.
Prof. Dr. Dr. Anne Albrecht
PI at Neuroanatomy, Institute of Anatomy, OVGU & Ombudsperson SynAGE
My work aims for understanding neuronal mechanisms of
stress resilience and vulnerability. Usually individuals cope well with
aversive experiences, but if they become too intense or last too long,
stress-induced neuropsychopathologies such as anxiety disorders or depression
can occur. Using different models of stress in juvenile and adult rodents, we
study how stress across the life span affects anxiety, learning and memory.
Specifically we are interested on how such stress experiences shape local
GABAergic interneuron circuits, signaling by modulatory neuropeptides as well
as astrocyte-neuron-interactions in the dorsal and ventral hippocampus. To that
end, we utilize biochemical and molecular tools such as high-resolution gene
expression analysis with laser microdissection and quantitative PCR and combine
it with testing emotional and cognitive functions in transgenic mice and after
acute pharmacological and viral interventions.
My work focuses on the role of the dopaminergic and noradrenergic systems in age-related episodic memory decline. Specifically, I investigate whether L-DOPA administration improves memory consolidation in healthy older adults. Furthermore, I will explore to what extent the variance of the MTL, the volume of medial temporal lobe memory structures and the volume/signal intensity of SN and LC mediate the memory outcomes.
A good maintenance of autophagy has been linked to longer lifespan, and reduced age-related diseases in many model organisms, In my PhD project I am trying to find novel pathways that regulate this process, as well as potential interventions that could prevent cognitive impairment during ageing. For that, I use neuronal culture, as well as protein biochemistry and behavioural experiments.
MD Candidate Project 12, SynAGE MD Representative
In my project I am focusing on the noradrenergic neuromodulatory system especially in preclinical Alzheimer’s disease. I use volume measures of specific brain regions reflecting a noradrenergic high or low content and analyze their associations to possible disease predicting factors CSF biomarkers, genetic and external risk factors in healthy and non-healthy elderly subjects within a structural equation model.
Dr. Anika Dirks
Scientific Coordination of RTG 2413 SynAGE
After studying Biochemistry at the Martin Luther University Halle, I did my PhD in Molecularbiology and Neurochemistry at the Leibniz Institute for Neurobiologie Magdeburg. During that time, my life focused on the presynapse-to-nucleus shuttling protein CtBP1.
Since 2017, I have worked as scientific coordinator at LIN and OVGU, especially at the center for behavioral brain sciences cbbs and the cbbs graduate program. I like to help young motivated students to complete their MD or PhD, which I am looking forward to continue and intensify at SynAGE.
Since June 2021 I am supporting Prof. Dr. Daniela Dieterich and SynAGE especially in financial concerns. I am looking forward to work with and assist young scientists on their way to become independent reseachers.
The aim of the CBBS graduate program is to connect students from the Otto von Guericke University (OVGU), the Leibniz Institute for Neurobiology (LIN) and the German Center for Neurodegenerative Diseases (DZNE).
Under the umbrella of the Otto von Guericke Graduate Academy (OVG-GA), you can find on their webpage useful information about upcoming events on the campus dealing with neuroscience, they organize lectures focusing on state-of-the-art methods used in neuroscience and organize social events.
Are you life-scientist? Are you connected to Magdeburg? Are you interested in networking with other researchers, join our events, be a mentor or seek one, share experiences about dual career or the balance of career and family? Then join our network via www.fsn.ovgu.de!
The goal of the FSN is to connect all life-scientists associated to Magdeburg- independent whether Magdeburg was the starting point, an intermediate stop or the goal of your career.
The task of the network is to connect alumnae and currently in Magdeburg working scientists, to win them as role models or mentors for future junior scientists and to highlight various career paths inside and outside academia.
The Female Scientists Network is a project funded by the CRC 854, RTG 2408 and RTG 2413. It started in June 2019.
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