TP1:Dysbalanced protein homeostasis as a hallmark and intervention target for aging cells? (Natalia Waal, Peter Landgraf and Daniela C. Dieterich) TP2:Autophagy mechanisms in the aging hippocampus (Carlos Miguel del Angel Munoz, Anne Albrecht and Oliver Stork) TP3:A nexus between DNA-hypomethylation and cognitive decline in healthy aging (Vsevolod Cherepashkin, Guilherme Gomes and Michael R. Kreutz) TP4:Molecular underpinnings of high-risk aging: Neuronal insulin signaling, amyloidosis and the metabolic syndrome (Eleonora Cuboni, Anna Karpova and Michael R. Kreutz) TP5:The effect of immunosenescence on synapse composition in a chronic neuroinflammation model (Tabea Linde, Johannes Steffen and Ildiko R. Dunay) TP6:Extracellular matrix-neuron-glia interactions during aging-associated cognitive decline and rejuvenation by ECM targeting (Hadi Mirzapourdelavar, Inseon Song, Rahul Kaushik and Alexander Dityatev) TP7:Targeting perisynaptic ECM mediated synaptic dysfunction in cerebral small vessel disease (Mahsima Khoshneviszadeh, Solveig Jandke, Rahul Kaushik, Stefanie Schreiber and Alexander Dityatev) TP8:The perisynaptic extracellular matrix (ECM) of the aging brain: impact of enriched environment and neuromodulation on ECM composition and cognitive performance (Jana Schulze, Eckart D. Gundelfinger and Constanze I. Seidenbecher) TP9:Mechanosensitive and astrocytic contributions to synaptic plasticity during aging (Danai Katsere, Anne Bayrhammer, Anke Müller and Daniela C. Dieterich) TP10:Hippocampal interneuron circuits during cognitive decline (Katharina Klinger, Gürsel Caliskan and Oliver Stork) TP11:Impact of stress on aging of BDNF-dependent synaptic and cognitive functions (Jeimmy Marcela Ceron Gonzalez, Thomas Endres and Volkmar Leßmann) TP12:Effects of L-DOPA on memory consolidation in high- and low-performing amyloid-negative older adults (Elisa Lancini, Dorothea Hammerer, Matthew Betts and Emrah Düzel) TP13:Learning from mistakes: Cholinergic modulation of interactions between performance monitoring and long-term memory (Alexander Weuthen and Markus Ullsperger)